1414 Main Street

Welcome to Keokuk, Iowa — a city where historic charm meets strategic commercial opportunity. Located in the southeast corner of Iowa and bordered by both Illinois and Missouri, Keokuk is uniquely positioned at the crossroads of three states. This tri-state access, combined with frontage along Main Street (which serves as both Highway 218 and Highway 61), makes this area a powerful draw for businesses looking to capture a wide and diverse market. 1414 Main Street sits along the city’s busiest corridor, boasting approximately 12,100 vehicles per day — a level of visibility that’s nearly unmatched in the region. Just blocks from national retailers like Walgreens, the property benefits from excellent co-tenancy and consistent customer traffic. Whether you're attracting walk-ins or destination clients, this location delivers brand exposure on a high-traffic, high-impact level. Keokuk itself is undergoing a quiet resurgence. Known as the “Gateway City to the West,” it offers an appealing blend of affordability, accessibility, and quality of life. The city is the largest in Lee County and continues to serve as a medical, educational, and commercial hub for the surrounding communities. With proximity to Southeast Iowa Regional Medical Center, local schools, and regional employers, Keokuk draws a stable workforce and a strong base of residents who value convenient, local services. From an investor’s perspective, this location checks every box: strong visibility, direct highway access, and the kind of community infrastructure that supports long-term tenancy and diversified business models. Out-of-state buyers will find Keokuk especially attractive for its low barriers to entry, high demand for local healthcare services, and a business-friendly environment supported by city leaders and regional economic development groups. In short, this is not just a building on Main Street — it’s a launchpad into a growing, underserved market in the heart of the Midwest.Introducing 1414 Main St, Keokuk, IA, 52632 – a prime commercial space available for lease. This versatile property boasts a highly visible location, making it ideal for retail, office space, or a variety of business endeavors. With ample parking and a sleek, modern facade, it offers both convenience and a professional image. Inside, the open floor plan provides endless layout possibilities, while large windows flood the space with natural light. Its proximity to key amenities ensures high foot traffic and a bustling environment. Don't miss the opportunity to elevate your business at this sought-after address.