South San Francisco, CA Commercial Real Estate for Lease and Sale

Explore 102 listings of South San Francisco commercial real estate to find the best space for your business.

220 South Linden Avenue

220 South Linden Avenue, Downtown South San Francisco, South San Francisco, CA
Property

Industrial

59,644 SF
Availability

1 Space

2,800 SF
Year Built

1937
For Lease

$1.95/SF/MO
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RETAIL SPACE FOR LEASE

348 Grand Ave, Downtown South San Francisco, South San Francisco, CA
Property

Retail
Availability

1 Space

3,000 SF
For Lease

$2.88/SF/MO
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WAREHOUSE BUILDING FOR LEASE AND SALE

216 Ryan Way, Lindenville, South San Francisco, CA
Property

Industrial
Availability

1 Space

3,600 SF
Year Built

1965
For Lease Contact for pricing
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6 S. Linden Avenue #7

6 S. Linden Avenue #7, Lindenville, South San Francisco, CA
Property

Industrial

2,144 SF
For Sale Contact for pricing
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Office Coworking Retail Industrial

Office Retail Industrial Land
ReadySpaces South San Francisco Harris

233 East Harris Avenue, The East Side, South San Francisco, CA
Property

Industrial

60,225 SF
Availability

1 Space

5,000 SF
Year Built

1975
For Lease Contact for pricing
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250 South Maple Avenue

250 South Maple Avenue, Lindenville, San Francisco, CA
Property

Industrial

7,500 SF
Availability

2 Spaces

7,500 SF
Year Built

2022
For Lease

$2.05/SF/MO
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889 McLellan Drive

889 McLellan Drive, Sunshine Gardens, South San Francisco, CA
Property

Retail

5,498 SF
For Sale

$5,498,000
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407 Cabot Road

407 Cabot Rd, The East Side, South San Francisco, CA
Property

Industrial

17,000 SF
Availability

2 Spaces

1,649 SF
Year Built

1965
For Lease

$5.00/SF/MO
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OFFICE SPACE FOR LEASE

301 Grand Ave, Downtown South San Francisco, South San Francisco, CA
Property

Office
Availability

1 Space

3,689 SF
Year Built

1973
For Lease

$1.00 - $2.75/SF/MO
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Park N Fly

101 TERMINAL CT, Lindenville, South San Francisco, CA
Property

VacantLand

378,068 SF
Availability

1 Space

378,068 SF
For Lease

$0.60/SF/MO
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Gellert Marketplace

2245 Gellert Blvd & Westborogh Blvd, North Westborough, South San Francisco, CA
Property

Retail

65,980 SF
Availability

1 Space

65,980 SF
For Lease Contact for pricing
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312 Harbor Way

312 Harbor Way, The East Side, South San Francisco, CA
Property

Industrial

31,478 SF
Year Built

1962
For Sale Contact for pricing
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SPUR Phase I (IQHQ)

580 Dubuque Avenue/SPUR Phase I (IQHQ), Gateway, S San Francisco, CA
Property

Unassigned

350,000 SF
Availability

10 Spaces

350,000 SF
Year Built

2025
For Lease

$93.00/SF/YR
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WAREHOUSE BUILDING FOR LEASE AND SALE

212-218 Ryan Way, Lindenville, South San Francisco, CA
Property

Industrial
Availability

1 Space

5,400 SF
Year Built

1965
For Lease Contact for pricing
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458 Carlton Ct

458 Carlton Ct, The East Side, South San Francisco, CA
Property

Industrial

4,876 SF
Availability

1 Space

2,627 SF
For Lease

$5.00/SF/MO
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1341 San Mateo Ave

1341 San Mateo Ave, Lindenville, South San Francisco, CA
Property

Office

27,008 SF
For Sale Contact for pricing
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Vantage - Building B

494 Forbes Blvd, The East Side, South San Francisco, CA
Property

Office

188,000 SF
Availability

5 Spaces

156,667 SF
Year Built

2024
For Lease Contact for pricing
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175 Sylvester

175 Sylvester Rd, Gateway, S San Francisco, CA
Property

Industrial

74,562 SF
Availability

1 Space

74,562 SF
Year Built

1957
For Lease Contact for pricing
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WAREHOUSE BUILDING FOR LEASE AND SALE

212-218 Ryan Way, Lindenville, South San Francisco, CA
Property

Industrial

15,257 SF
Year Built

1965
For Sale Contact for pricing
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GATEWAY COMMONS

701 Gateway Blvd , Gateway, South San Francisco, CA
Property

Office
Availability

1 Space

29,470 SF
Year Built

1998
For Lease

$2.00/SF/MO
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161 Starlite Street

161 Starlite Street, Lindenville, South San Francisco, CA
Property

Industrial

60,622 SF
Availability

1 Space

27,990 SF
Year Built

1961
For Lease

$1.75/SF/MO
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6 S. Linden Avenue #6

6 S. Linden Avenue, Lindenville, South San Francisco, CA
Property

Industrial

2,067 SF
For Sale Contact for pricing
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410 Grand

410 Grand Ave, E., The East Side, S San Francisco, CA
Property

Industrial

22,270 SF
Availability

1 Space

22,270 SF
Year Built

1980
For Lease Contact for pricing
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RETAIL SPACE FOR LEASE

400 S Airport Blvd, San Bruno Canal, South San Francisco, CA
Property

Retail
Availability

1 Space

5,124 SF
Year Built

1965
For Lease Contact for pricing
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228-230 Shaw Road

228 Shaw Road, Lindenville, South San Francisco, CA
Property

Industrial

66,000 SF
Availability

1 Space

65,571 SF
Year Built

1957
For Lease

$1.50/SF/MO
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486 Cabot

486 Cabot Rd, The East Side, S San Francisco, CA
Property

Unassigned

16,000 SF
Availability

1 Space

6,275 SF
Year Built

1967
For Lease Contact for pricing
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60 Airport Boulevard South San Francisco

60 Airport Boulevard South San Francisco, Downtown South San Francisco, South San Francisco, CA
Property

Industrial

36,000 SF
Availability

1 Space

36,000 SF
For Lease

$60,000.00/MO
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1455-1475 Mission Road

1455 - 1475 MISSION RD, Sunshine Gardens, South San Francisco, CA
Property

Industrial

12,600 SF
Availability

1 Space

4,000 SF
For Lease Contact for pricing
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201 Cypress Ave

201 Cypress Ave, Downtown South San Francisco, South San Francisco, CA
Property

Industrial

10,067 SF
For Sale

$2,900,000
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264 S Maple Ave

264 S Maple Ave, Lindenville, South San Francisco, CA
Property

Industrial

24,291 SF
Year Built

1971
For Sale Contact for pricing
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Kilroy Oyster Point - 384 Oyster Point Blvd

384 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Industrial

57,444 SF
Availability

22 Spaces

906,334 SF
Year Built

1985
For Lease

$7.25/SF/MO
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Kilroy Oyster Point - Phase 5

349 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

700,000 SF
Availability

1 Space

65,340 SF
For Lease Contact for pricing
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Gateway of Pacific V - North Building

475 Eccles Avenue, The East Side, South San Francisco, CA
Property

Office

160,000 SF
Availability

4 Spaces

129,600 SF
Year Built

2024
For Lease

$7.25/SF/MO
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WAREHOUSE BUILDING FOR LEASE AND SALE

216 Ryan Way, Lindenville, South San Francisco, CA
Property

Industrial

15,257 SF
Year Built

1965
For Sale Contact for pricing
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486 Cabot Rd

486 Cabot Rd, The East Side, South San Francisco, CA
Property

Industrial

16,008 SF
Availability

1 Space

13,500 SF
Year Built

1966
For Lease

$1.75/SF/MO
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6 S Linden Ave

6 S Linden Ave, Lindenville, South San Francisco, CA
Property

Industrial

2,067 SF
For Sale Contact for pricing
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100 Grand

100 Grand Ave, E., Downtown South San Francisco, S San Francisco, CA
Property

Industrial

70,728 SF
Availability

1 Space

70,728 SF
Year Built

1954
For Lease Contact for pricing
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PS BUSINESS PARK

156 S Spruce Ave, Orange Park, South San Francisco, CA
Property

Office
Availability

2 Spaces

1,393 SF
For Lease

$1.60/SF/MO
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Gateway of Pacific IV

900 Gateway Blvd, The East Side, San Francisco, CA
Property

Office

405,000 SF
Availability

9 Spaces

249,993 SF
For Lease Contact for pricing
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1 S Linden Ave

1 S Linden Ave, Lindenville, South San Francisco, CA
Property

Industrial

29,950 SF
Availability

1 Space

3,400 SF
Year Built

1941
For Lease

$2.00/SF/MO
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930 Linden Ave

930 Linden Ave, Downtown South San Francisco, South San Francisco, CA
Property

Industrial

11,969 SF
Year Built

1952
For Sale

$4,195,000
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Oyster Point Business Park - Bldg H

384 OYSTER POINT BLVD, Oyster Point, South San Francisco, CA
Property

Industrial

71,333 SF
Availability

4 Spaces

21,538 SF
For Lease

$1.75/SF/MO
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406 Cabot Road

406 Cabot Road, The East Side, South San Francisco, CA
Property

VacantLand

17,000 SF
Availability

1 Space

12,000 SF
Year Built

1965
For Lease

$1.00/SF/MO
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Gateway of Pacific V - South Building

475 Eccles Avenue, The East Side, South San Francisco, CA
Property

Office

160,000 SF
Availability

4 Spaces

144,700 SF
Year Built

2024
For Lease

$7.25/SF/MO
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988 El Camino Real

988 El Camino Real, Orange Park, South San Francisco, CA
Property

Retail

10,000 SF
Availability

3 Spaces

2,231 SF
Year Built

2022
For Lease Contact for pricing
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Kilroy Oyster Point - Buildings D, E & F

389 Oyster Point Blvd, Oyster Point, San Francisco, CA
Property

Office

865,000 SF
Availability

1 Space

3,329 SF
Year Built

2025
For Lease

$2.00/SF/MO
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149-151 Linden

149 Linden Ave, S., Lindenville, S San Francisco, CA
Property

Industrial

13,000 SF
Availability

1 Space

3,500 SF
For Lease Contact for pricing
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200 Airport Blvd

200 Airport Blvd, San Bruno Canal, South San Francisco, CA
Property

Retail

3,634 SF
Availability

1 Space

1,977 SF
For Lease Contact for pricing
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Cabot, Cabot & Forbes

439 Eccles Ave, The East Side, S San Francisco, CA
Property

Industrial

40,200 SF
Availability

1 Space

40,200 SF
Year Built

1960
For Lease Contact for pricing
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Southline - Building 1

30 Tanforan Avenue, Lindenville, South San Francisco, CA
Property

Office

375,000 SF
Availability

1 Space

325,000 SF
Year Built

2024
For Lease Contact for pricing
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Frequently Asked Questions

Commercial real estate is a broad category that includes a high variety of space types designed to meet the needs of various industries of the local economy and their specialized subsectors, as presented in our real estate 101 guide to types of commercial real estate. However, there are three main categories that you are most likely to come across: office, retail, and industrial space.

Modern office space is typically organized over large floor plates bound by high ceilings and large windows for an abundance of natural light and is located in transit-oriented developments with good access to multiple modes of transportation, so as to facilitate employee commute. The South San Francisco commercial real estate market incorporates 7,468,252 square feet of office space across 42 buildings.

Office buildings can also accommodate coworking spaces, which are shared office options that typically cater to the needs of small, startup businesses that require flexible workspaces, a concentration of amenities, and services that can be accessed on an occasional or short-term basis.
Retail space includes shopping malls, department stores, street retail, or specialty stores dedicated to a narrow range of products. Such properties are typically located in high foot-traffic and/or car traffic areas, to facilitate customer access. The South San Francisco commercial real estate market includes 85,112 square feet of retail space in a variety of settings.
Industrial property most often serves businesses operating in manufacturing or logistics and generally consists of large open spaces located within good access to roads, railways, freight airports or regional water ports. Industrial space listings can include warehouses, manufacturing plants, distribution centers, flexible industrial space, or even data center facilities. Across the South San Francisco market, there is a total of 2,372,719 square feet of industrial property.

The listing inventory in South San Francisco incorporates commercial real estate for lease and for sale of almost all property types and subtypes. However, you’ll find some categories offer more rental or investment opportunities than others.

The largest share of commercial real estate space for lease in South San Francisco is represented by Office space, which accounts for 2,513,896 square feet of available listings. Industrial space available in South San Francisco adds up to 1,674,900 square feet.

Meanwhile, most of the listings of commercial property for sale in South San Francisco are in the Industrial category.

The price of renting or buying commercial real estate is influenced by a variety of factors, including: the property type (for example, office space is priced higher than other property types in most locations); the condition and asset class rating (property rated class A or above will typically command a higher price than lower grade classifications); the quality or the development potential of the property location; whether or not there is high demand for the type of commercial asset in question; and what the state of supply is relative to demand.

The average rent for commercial real estate space listed for lease in South San Francisco is $77.6 per square foot. However, this value does not offer enough perspective on its own, as you will find significant variation in prices across property types, property classes, and location, as well as other impacting factors. For instance, rent per square foot of office space in South San Francisco can vary greatly depending on the rating of the property from Class A to Class C, as well as across the city depending on the location of the asset. What’s more, each commercial property type makes its own rent market: while the average rent for office space rested at $48.02 per square foot, industrial space in South San Francisco saw average rents of $81.69 per square foot.

Whether you are looking for commercial real estate for lease or commercial property for sale, the best choice of location depends on the factors that are most relevant to your business strategy. A good thing to look for at the start, however, is the areas of the city that have the highest concentration of your preferred type of property, as these areas are generally well connected to the amenities and points of interest that are most relevant to each property type.

As such, there are several areas that you could consider to be the best location for commercial real estate in South San Francisco, depending on the property type you are interested in. The highest concentration of commercial space listings of any kind in South San Francisco is in the The East Side neighborhood. But if we look at each commercial property type, we find that for office space, the best location is the The East Side area.

Meanwhile, retail space opportunities are most abundant in the Orange Park submarket. Alternatively, if you are looking for warehouse or other industrial space, consider looking at listings in The East Side.

Select your preferred property type from the search filters menu at the top of the search page and then navigate the interactive map for a better view of commercial real estate availability in the locations most suited to your needs.

Regardless of whether buying or leasing commercial space is a new experience for you, there are significant benefits to working with a commercial real estate broker. In addition to saving you time and money, an experienced broker will contribute specialist knowledge of the local market, the property type you need representation for, and will handle negotiations on your behalf in your best interest.

To start, it is important for you to have a good understanding of what kind of broker you need. For instance, there are differences between a tenant broker and a listing broker. Also important at the start is to have a clear idea of what kind of space (or tenant) you are looking for and what (if any) particular needs and requirements you might have. And, while it is good to get a referral, you should interview several brokers to better gauge who you feel would best represent your interests.

CommercialCafe hosts listings from some of the most trusted commercial real estate brokerages in the country. Use the contact form available on each listing page or the contact details for the property representatives to reach out and start your search!

The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself — which itself includes aspects such as location, property class, amenities, and the quality of the property management — to the local market conditions, the state of the local economy, the demand for that particular type of commercial property, and of course the costs of owning and maintaining it relative to what leasing rate or sale price you get from the property. Asking rents in the city went as high as $87 per square foot. In particular, the property type commanding the highest lease rates in South San Francisco was Industrial space.

The average size of a commercial property in South San Francisco depends greatly on the property type and the location — geographical possibilities and zoning allowances have significant influence on how big developers can build. While there are outliers that break height or volume records in the city, we can look at some average sizes by property use:

In South San Francisco, the average size of an office property is 213,379 square feet.
Retail properties here incorporate an average of 21,278 square feet.
Industrial space in South San Francisco is in buildings that are, on average 59,318 square feet in size.

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial real estate listings for rent in South San Francisco currently add up to 4,641,332 square feet. The market offers 39 active office listing(s), which amount to 3,383,451 square feet and account for 49% of commercial spaces on the market. Local retail availability includes 78,312 square feet across 5 retail space(s). Industrial space for rent opportunities in South San Francisco amount to 789,501 square feet across a total of 31 warehouse and other industrial listing(s).

Property Type	Count of Listings	Total SF
Office	39	3,383,451
Retail	5	78,312
Industrial	31	789,501
Other	4	390,068

Commercial Space for Sale Breakdown

What’s more, if you are interested in making an investment in the local market, you can also find commercial real estate for sale in South San Francisco, CA. Currently, there is 517,490 square feet of commercial property for sale here , which includes 1 office building(s) for sale , 2 retail investment opportunity listing(s) , and 16 listing(s) of industrial real estate property for sale .

Property Type	Count of Listings	Total SF
Office	1	27,008
Retail	2	9,248
Industrial	16	459,259
Other	1	21,975

South San Francisco, CA Commercial Real Estate for Lease and Sale

Frequently Asked Questions

What are the different types of commercial real estate?

What types of commercial real estate are available in South San Francisco, CA?

What factors affect the price of commercial real estate in South San Francisco, CA?

What is the average rent for commercial space in South San Francisco, CA?

What are the best areas for commercial real estate in South San Francisco, CA?

How do I find a good commercial real estate broker?

What is the most profitable commercial real estate?

What is the average size of a commercial property in South San Francisco, CA?

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial Space for Sale Breakdown

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