San Bruno, CA Office Spaces for Rent

Find the best San Bruno, CA office space among 41 for rent listings currently on the market.

San Bruno Medical Office Building

1001 Sneath Lane, San Bruno, CA
Property

Office

32,658 SF
Availability

1 Space

5,414 SF
For Lease

$45.00/SF/YR
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1250 Grundy Lane

1250 Grundy Lane, San Bruno, CA
Property

Office

21,217 SF
Availability

1 Space

9,800 SF
For Lease Contact for pricing
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The Gateway Technology Center - 650 Gateway Blvd

650 Gateway Blvd, The East Side, South San Francisco, CA
Property

Office

50,400 SF
Availability

2 Spaces

15,234 SF
Year Built

1999
For Lease Contact for pricing
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The Nexus on Grand

233 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

148,500 SF
Availability

2 Spaces

53,682 SF
Year Built

2023
For Lease Contact for pricing
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Edgewater Science Park

260 Littlefield Avenue, The East Side, South San Francisco, CA
Property

Office

169,359 SF
Availability

3 Spaces

52,807 SF
Year Built

1988
For Lease Contact for pricing
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395 Oyster Point Blvd

395 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

234,480 SF
Availability

1 Space

25,000 SF
Year Built

1987
For Lease Contact for pricing
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The Cove at Oyster Point III

151 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

153,047 SF
Availability

1 Space

14,432 SF
Year Built

2016
For Lease Contact for pricing
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The Shore at Sierra Point - Building B & C

1600 Sierra Point Pkwy, Brisbane, CA
Property

Office

297,634 SF
Availability

5 Spaces

195,888 SF
Year Built

2022
For Lease Contact for pricing
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7000 Shoreline Court

7000 Shoreline Court, Paradise Valley, South San Francisco, CA
Property

Office

136,395 SF
Availability

1 Space

4,746 SF
Year Built

2003
For Lease Contact for pricing
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Alexandria Center for Science and Technology at Mission Bay - 450 East Jamie Court

450 East Jamie Court, The East Side, South San Francisco, CA
Property

Office

74,788 SF
Availability

2 Spaces

59,502 SF
Year Built

2009
For Lease Contact for pricing
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Sierra Point Towers - 8000 Marina Blvd

8000 Marina Blvd, Brisbane, CA
Property

Office

201,859 SF
Availability

2 Spaces

41,043 SF
Year Built

2000
For Lease Contact for pricing
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Britannia Oyster Point II - Building B

331 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

128,751 SF
Availability

4 Spaces

134,237 SF
Year Built

2008
For Lease Contact for pricing
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Genesis - North Tower

2 Tower Place, Paradise Valley, South San Francisco, CA
Property

Office

381,523 SF
Availability

3 Spaces

46,362 SF
Year Built

2018
For Lease Contact for pricing
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Bayshore Office Center

1633 Bayshore Hwy, Burlingame, CA
Property

Office

104,610 SF
Availability

10 Spaces

9,372 SF
Year Built

1974
For Lease

$35.40/SF/YR
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Britannia Oyster Point I - C

1140 Veterans Blvd, Oyster Point, South San Francisco, CA
Property

Office

67,000 SF
Availability

3 Spaces

69,058 SF
Year Built

2003
For Lease Contact for pricing
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Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.

Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in San Bruno, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 9,800 square feet in size for an individual listing.

You can find 2 office listing(s) for lease in San Bruno, which add up to a total of 12,198 square feet. Availability on the market includes a variety of office use types, such as General Office, Medical Office.

The most common office use type currently available for lease in San Bruno is General Office, which is offered in 1 or 50.00% of listings. The second-most frequent office use type listed here is Medical Office, which account for 1 or 50.00% of office space currently available.

Sublease opportunities on the market include General Office, Medical Office.

The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.

Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.

The San Bruno office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Roughly 50% of total office space listings in the city are in properties rated Class A. Class B office space accounts for 50% of spaces listed on the leasing market.

There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.

Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of San Bruno? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

San Bruno, CA Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in San Bruno: 1,800,381 Sq. Ft.

In 2024 the San Bruno office market encompassed 1,800,381 square feet of space.
Class A office space makes up a 82.34% share of San Bruno office inventory, while Class B office assets represent roughly 13.21% of the market total.

San Bruno Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	319,732 Sq. Ft.	17.76%
100k to 500k Sq. Ft.	1,436,473 Sq. Ft.	79.79%

San Bruno Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	1,482,449 Sq. Ft.	82.34%
Class B	237,762 Sq. Ft.	13.21%
Class C	80,170 Sq. Ft.	4.45%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

San Bruno, CA Office Spaces for Rent

San Bruno Medical Office Building

1250 Grundy Lane

The Gateway Technology Center - 650 Gateway Blvd

The Nexus on Grand

Edgewater Science Park

395 Oyster Point Blvd

The Cove at Oyster Point III

The Shore at Sierra Point - Building B & C

7000 Shoreline Court

Alexandria Center for Science and Technology at Mission Bay - 450 East Jamie Court

Sierra Point Towers - 8000 Marina Blvd

Britannia Oyster Point II - Building B

Genesis - North Tower

Bayshore Office Center

Britannia Oyster Point I - C

Frequently Asked Questions

San Bruno, CA Office Inventory Breakdown

Total Office Space in San Bruno: 1,800,381 Sq. Ft.

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San Bruno, CA Office Spaces for Rent

Frequently Asked Questions

How much does office space cost in San Bruno, CA?

How much office space do I need?

What types of office space can I lease in San Bruno, CA?

Can I find sublease office space in San Bruno, CA?

Where is the best location for office space in San Bruno, CA?

How long is the average commute to work in San Bruno, CA?

Where can I find the highest quality office space in San Bruno, CA?

How do I find the best office space in San Bruno, CA?

How can I find office space for rent near me?

San Bruno, CA Office Inventory Breakdown

Total Office Space in San Bruno: 1,800,381 Sq. Ft.

Other Popular Searches

Popular Coworking Searches

Popular Commercial Searches

About us