South San Francisco, CA Office Spaces for Rent

Find your best South San Francisco, CA office space among 128 for rent listings, which average an asking price of $48.02 per square foot.

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The Gateway Technology Center - 650 Gateway Blvd

650 Gateway Blvd, The East Side, South San Francisco, CA
Property

Office

50,400 SF
Availability

2 Spaces

15,234 SF
Year Built

1999
For Lease Contact for pricing
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395 Oyster Point Blvd

395 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

234,480 SF
Availability

1 Space

25,000 SF
Year Built

1987
For Lease Contact for pricing
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The Cove at Oyster Point III

151 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

153,047 SF
Availability

1 Space

14,432 SF
Year Built

2016
For Lease Contact for pricing
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7000 Shoreline Court

7000 Shoreline Court, Paradise Valley, South San Francisco, CA
Property

Office

136,395 SF
Availability

1 Space

4,746 SF
Year Built

2003
For Lease Contact for pricing
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Alexandria Center for Science and Technology at Mission Bay - 450 East Jamie Court

450 East Jamie Court, The East Side, South San Francisco, CA
Property

Office

74,788 SF
Availability

2 Spaces

59,502 SF
Year Built

2009
For Lease Contact for pricing
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Britannia Oyster Point II - Building B

331 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

128,751 SF
Availability

4 Spaces

134,237 SF
Year Built

2008
For Lease Contact for pricing
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The Nexus on Grand

233 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

148,500 SF
Availability

2 Spaces

53,682 SF
Year Built

2023
For Lease Contact for pricing
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Genesis - North Tower

2 Tower Place, Paradise Valley, South San Francisco, CA
Property

Office

381,523 SF
Availability

3 Spaces

46,362 SF
Year Built

2018
For Lease Contact for pricing
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Edgewater Science Park

260 Littlefield Avenue, The East Side, South San Francisco, CA
Property

Office

169,359 SF
Availability

3 Spaces

52,807 SF
Year Built

1988
For Lease Contact for pricing
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Britannia Oyster Point I - C

1140 Veterans Blvd, Oyster Point, South San Francisco, CA
Property

Office

67,000 SF
Availability

3 Spaces

69,058 SF
Year Built

2003
For Lease Contact for pricing
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Genesis - South Tower

1 Tower Place, Paradise Valley, South San Francisco, CA
Property

Office

324,986 SF
Availability

6 Spaces

162,281 SF
Year Built

2009
For Lease Contact for pricing
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Alexandria Center for Science and Technology at Mission Bay - 400 East Jamie Court

400 East Jamie Court, The East Side, South San Francisco, CA
Property

Office

88,284 SF
Availability

1 Space

7,833 SF
Year Built

2009
For Lease Contact for pricing
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Britannia Pointe Grand

250 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

630,500 SF
Availability

8 Spaces

202,210 SF
Year Built

1989
For Lease Contact for pricing
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400 Oyster Point Blvd

400 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

234,480 SF
Availability

2 Spaces

42,314 SF
Year Built

1985
For Lease

$33.00/SF/YR
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Produce Avenue Business Park

100 Produce Avenue, Lindenville, South San Francisco, CA
Property

Office

41,448 SF
Availability

2 Spaces

3,917 SF
Year Built

1986
For Lease

$0.80 - $1.50/SF/MO
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201 Haskins Way

201 Haskins Way, The East Side, South San Francisco, CA
Property

Office

311,368 SF
Availability

2 Spaces

36,163 SF
Year Built

2021
For Lease

$72.00/SF/YR
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Britannia Oyster Point II - Building A

333 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

121,760 SF
Availability

1 Space

30,140 SF
Year Built

2008
For Lease Contact for pricing
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Gateway Commons

611 Gateway Blvd, Gateway, S San Francisco, CA
Property

Office

260,337 SF
Availability

1 Space

24,512 SF
Year Built

2002
For Lease

$47.40/SF/YR
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Britannia Modular Labs IV

100 Kimball Way, The East Side, South San Francisco, CA
Property

Office

104,930 SF
Availability

2 Spaces

25,991 SF
Year Built

1968
For Lease Contact for pricing
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The Cove at Oyster Point IV

171 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

140,053 SF
Availability

1 Space

4,968 SF
Year Built

2016
For Lease Contact for pricing
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Gateway Crossing - 201 & 225 Gateway Blvd

225 Gateway Blvd, Gateway, South San Francisco, CA
Property

Office

106,076 SF
Availability

3 Spaces

68,197 SF
Year Built

1998
For Lease Contact for pricing
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The Cove at Oyster Point VII

131 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

175,830 SF
Availability

2 Spaces

49,093 SF
Year Built

2019
For Lease Contact for pricing
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343 Oyster Point Blvd

343 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

53,980 SF
Availability

2 Spaces

34,090 SF
Year Built

2001
For Lease Contact for pricing
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6000 Shoreline Court

6000 Shoreline Court, Paradise Valley, South San Francisco, CA
Property

Office

139,372 SF
Availability

5 Spaces

43,017 SF
Year Built

2001
For Lease Contact for pricing
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PS BUSINESS PARK

90 S Spruce Ave, Orange Park, South San Francisco, CA
Property

Office
Availability

6 Spaces

8,722 SF
Year Built

1986
For Lease

$1.45 - $1.95/SF/MO
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5000 Shoreline Court

5000 Shoreline Court, Paradise Valley, South San Francisco, CA
Property

Office

138,399 SF
Availability

5 Spaces

84,537 SF
Year Built

2000
For Lease Contact for pricing
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The Gateway North Campus - 901 Gateway Blvd

901 Gateway Blvd, Gateway, South San Francisco, CA
Property

Office

110,428 SF
Availability

3 Spaces

78,070 SF
Year Built

2000
For Lease

$4.50/SF/MO
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Britannia Modular Labs I

285 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

61,770 SF
Availability

2 Spaces

62,000 SF
Year Built

2006
For Lease Contact for pricing
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Victory Business Center

441 Victory Avenue, Lindenville, South San Francisco, CA
Property

Industrial

32,954 SF
Availability

2 Spaces

6,766 SF
Year Built

1990
For Lease

$1.95/SF/MO
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1 Corporate Drive
Bonneville Labs
1 Corporate Drive, South San Francisco, CA
Services

Meeting Room

Private Office

Dedicated Desk
Amenities

Complimentary coffee & tea

Free water

High-speed wifi

IT support

Printer
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750 Gateway Boulevard
Bonneville Labs
750 Gateway Boulevard, South San Francisco, CA
Services

Meeting Room

Private Office

Dedicated Desk
Amenities

IT support

Lab space

Storage area
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Gateway of Pacific IV

900 Gateway Blvd, The East Side, San Francisco, CA
Property

Office

405,000 SF
Availability

9 Spaces

249,993 SF
For Lease Contact for pricing
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Kilroy Oyster Point - 384 Oyster Point Blvd

384 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Industrial

57,444 SF
Availability

22 Spaces

906,334 SF
Year Built

1985
For Lease

$7.25/SF/MO
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PS BUSINESS PARK

156 S Spruce Ave, Orange Park, South San Francisco, CA
Property

Office
Availability

2 Spaces

1,393 SF
For Lease

$1.60/SF/MO
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Kilroy Oyster Point - Phase 5

349 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

700,000 SF
Availability

1 Space

65,340 SF
For Lease Contact for pricing
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Gateway of Pacific V - North Building

475 Eccles Avenue, The East Side, South San Francisco, CA
Property

Office

160,000 SF
Availability

4 Spaces

129,600 SF
Year Built

2024
For Lease

$7.25/SF/MO
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Gateway of Pacific V - South Building

475 Eccles Avenue, The East Side, South San Francisco, CA
Property

Office

160,000 SF
Availability

4 Spaces

144,700 SF
Year Built

2024
For Lease

$7.25/SF/MO
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Southline - Building 1

30 Tanforan Avenue, Lindenville, South San Francisco, CA
Property

Office

375,000 SF
Availability

1 Space

325,000 SF
Year Built

2024
For Lease Contact for pricing
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407 Cabot Road

407 Cabot Rd, The East Side, South San Francisco, CA
Property

Industrial

17,000 SF
Availability

2 Spaces

1,649 SF
Year Built

1965
For Lease

$5.00/SF/MO
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OFFICE SPACE FOR LEASE

301 Grand Ave, Downtown South San Francisco, South San Francisco, CA
Property

Office
Availability

1 Space

3,689 SF
Year Built

1973
For Lease

$1.00 - $2.75/SF/MO
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Brentwood Center

128 Brentwood Dr, Brentwood Park, South San Francisco, CA
Property

Retail

18,767 SF
Availability

2 Spaces

2,778 SF
Year Built

1952
For Lease Contact for pricing
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Vantage - Building B

494 Forbes Blvd, The East Side, South San Francisco, CA
Property

Office

188,000 SF
Availability

5 Spaces

156,667 SF
Year Built

2024
For Lease Contact for pricing
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Kilroy Oyster Point - Buildings D, E & F

389 Oyster Point Blvd, Oyster Point, San Francisco, CA
Property

Office

865,000 SF
Availability

1 Space

3,329 SF
Year Built

2025
For Lease

$2.00/SF/MO
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GATEWAY COMMONS

701 Gateway Blvd , Gateway, South San Francisco, CA
Property

Office
Availability

1 Space

29,470 SF
Year Built

1998
For Lease

$2.00/SF/MO
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Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.

The average rent for office space in South San Francisco is $48.02 per square foot. The minimum rental rate for office space in South San Francisco is $9.6 per square foot. Among listings of office space currently available for lease in South San Francisco, the maximum rental rate is $54 per square foot.

The most common factor that influences cost of office space in any location is the property class rating. For example, South San Francisco office space rated Class A asks an average of $51.49 per square foot. Class B office space in South San Francisco costs $44.65 per square foot, on average.

For more details on South San Francisco office space rent and sales prices, as well as overall market quality and new construction data, see South San Francisco Office Market Trends.

Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in South San Francisco, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 325,000 square feet in size for an individual listing.
However, there is a variety of differently sized opportunities below that maximum. For your consideration, the median size of an office space for lease in South San Francisco is 20,545 square feet, and the average office space size here is 23,668 square feet.

You can find 128 office listing(s) for lease in South San Francisco, which add up to a total of 2,513,896 square feet. Availability on the market includes a variety of office use types, such as R&D - Office, General Office, Flex - Office, Medical Office.

The most common office use type currently available for lease in South San Francisco is R&D - Office, which is offered in 55 or 42.97% of listings. The second-most frequent office use type listed here is General Office, which account for 30 or 23.44% of office space currently available.

You can search 29 office sublease listing(s) in South San Francisco, which amount to a total of 572,196 square feet. Sublease opportunities on the market include General Office, R&D - Office, Flex - Office. The South San Francisco neighborhood or submarket with the most sublease listings available is The East Side.

The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.

In South San Francisco, the greatest concentration of office space for lease opportunities is in The East Side, Oyster Point, Paradise Valley.

Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.

The South San Francisco office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Roughly 60.94% of total office space listings in the city are in properties rated Class A. You will find the highest concentration of Class A office space in the Oyster Point neighborhood of South San Francisco. Class B office space accounts for 23.44% of spaces listed on the leasing market. The neighborhood with the most Class B office space is The East Side. Class C office space makes up 6.25% of office space available in South San Francisco.

Buildings completed in and since the year 2000 account for 58.54% of office properties in the city and incorporate a total of 4,764,571 square feet.

Out of the office space listings currently available in South San Francisco, you can find 21 LEED-certified or LEED-proposed option(s). A total of 8 building(s) here earned a LEED-certification — certification levelPlatinum (2), Gold (2), Silver (2). The local market includes 2 LEED-proposed office building(s) awaiting certification in South San Francisco.

There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.

Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of South San Francisco? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

South San Francisco, CA Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in South San Francisco: 16,297,583 Sq. Ft.

In 2024 the South San Francisco office market encompassed 16,297,583 square feet of space. Out of that total, 1,795,500 square feet were in office properties sized between 500,000 and 1,000,000 square feet. Meanwhile, 2,107,392 square feet were in office buildings sized between 50,000 and 100,000 square feet.
Class A office space makes up a 76.47% share of South San Francisco office inventory, while Class B office assets represent roughly 23.03% of the market total.

South San Francisco Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	2,107,392 Sq. Ft.	12.93%
100k to 500k Sq. Ft.	10,572,964 Sq. Ft.	64.87%
500k to 1M Sq. Ft.	1,795,500 Sq. Ft.	11.02%
> 1M Sq. Ft.	1,408,361 Sq. Ft.	8.64%

South San Francisco Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	12,462,332 Sq. Ft.	76.47%
Class B	3,753,129 Sq. Ft.	23.03%
Class C	82,122 Sq. Ft.	0.5%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

South San Francisco, CA Office Spaces for Rent

Frequently Asked Questions

How much does office space cost in South San Francisco, CA?

How much office space do I need?

What types of office space can I lease in South San Francisco, CA?

Can I find sublease office space in South San Francisco, CA?

Where is the best location for office space in South San Francisco, CA?

How long is the average commute to work in South San Francisco, CA?

Where can I find the highest quality office space in South San Francisco, CA?

How do I find the best office space in South San Francisco, CA?

How can I find office space for rent near me?

South San Francisco, CA Office Inventory Breakdown

Total Office Space in South San Francisco: 16,297,583 Sq. Ft.

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