Santee, CA Office Spaces for Rent

Find the best Santee, CA office space among 21 for rent listings currently on the market.

9280 Mast Blvd

9280 Mast Blvd, Santee, CA
Property

Office

4,600 SF
Availability

1 Space

700 SF
Year Built

1990
For Lease Contact for pricing
View Details (opens in new window)
321 Van Houten Ave

321 Van Houten Ave, El Cajon, CA
Property

Office

6,412 SF
Availability

2 Spaces

6,500 SF
Year Built

1960
For Lease

$1.95 - $23.40/SF/YR
View Details (opens in new window)
270 East Douglas Avenue
East County Biz Center
270 East Douglas Avenue, El Cajon, CA
Services

Virtual Office

Open Workspace

Meeting Room

Private Office
Amenities

Business address

Fax services

High-speed wifi

Mail services

Parking

Photocopier

Printer

Projector

Receptionist/Secretarial services

TV/Monitor
View Details (opens in new window)
1345 Broadway

1345 Broadway, El Cajon, CA
Property

Office

1,400 SF
Availability

1 Space

1,400 SF
For Lease

$1.60/SF/MO
View Details (opens in new window)
5811 Amaya Drive
La Mesa Cowork
5811 Amaya Drive #100, La Mesa, CA
Services

Open Workspace
Amenities

24/7 security

Complimentary coffee & tea

High-speed internet

Kitchen

Parking

Pet friendly
View Details (opens in new window)
Fletcher Parkway Medical Center

8881 Fletcher Pkwy, La Mesa, CA
Property

Office

82,024 SF
Availability

4 Spaces

14,553 SF
Year Built

1985
For Lease Contact for pricing
View Details (opens in new window)
Grossmont Medical Terrace

8860 Center Drive, La Mesa, CA
Property

Office

65,000 SF
Availability

1 Space

3,343 SF
Year Built

2007
For Lease Contact for pricing
View Details (opens in new window)
Grossmont Medical Arts Building

8851 Center Drive, La Mesa, CA
Property

Office

70,222 SF
Availability

2 Spaces

8,108 SF
Year Built

1986
For Lease

$21.84/SF/YR
View Details (opens in new window)
Mollison Plaza

669 S Mollison Ave, El Cajon, CA
Property

Retail

9,100 SF
Availability

2 Spaces

1,965 SF
For Lease

$30.00/SF/YR
View Details (opens in new window)
Grossmont Medical Center - Bldg. 1

5565 Grossmont Center Dr., La Mesa, CA
Property

Office

28,632 SF
Availability

8 Spaces

14,964 SF
Year Built

1970
For Lease Contact for pricing
View Details (opens in new window)

Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.
Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in Santee, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 700 square feet in size for an individual listing.
You can find 1 office listing(s) for lease in Santee, which add up to a total of 700 square feet. Availability on the market includes a variety of office use types, such as General Office.

The most common office use type currently available for lease in Santee is General Office, which is offered in 1 or 100.00% of listings.
Sublease opportunities on the market include General Office.
The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.
Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.
The Santee office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Class C office space makes up 100% of office space available in Santee.
There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.
Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of Santee? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

Santee, CA Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in Santee: 130,929 Sq. Ft.

In 2025 the Santee office market encompassed 130,929 square feet of space.

Santee Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	72,875 Sq. Ft.	55.66%

Santee Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class B	130,929 Sq. Ft.	100%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

About us

CommercialCafe is your go-to commercial real estate listing source. We partner with highly respected major brokerages from across the country to ensure high-quality listings that are updated frequently. Our online marketplace lists all commercial property types from office, coworking, retail, and industrial to special purpose properties.

CommercialCafe is a trusted Yardi brand and is an integral part of the CommercialEdge network — the fastest-growing network of online real estate marketplaces, which ranks on the 1st page of Google for all top markets, attracts more than 2 million monthly visits, and generates more than 350,000 broker contacts.

Santee, CA Office Spaces for Rent

9280 Mast Blvd

321 Van Houten Ave

270 East Douglas Avenue

1345 Broadway

5811 Amaya Drive

Fletcher Parkway Medical Center

Grossmont Medical Terrace

Grossmont Medical Arts Building

Mollison Plaza

Grossmont Medical Center - Bldg. 1

Frequently Asked Questions

Santee, CA Office Inventory Breakdown

Total Office Space in Santee: 130,929 Sq. Ft.

Other Popular Searches

Popular Coworking Searches

Popular Commercial Searches

About us

About Us

Our Tools