Clayton, St. Louis County, MO Office Spaces for Rent

Find your best Clayton, St. Louis County, MO office space among 140 for rent listings, which average an asking price of $28.63 per square foot.

Office Market FAQs

Pierre Laclede I

7701 Forsyth Blvd., Clayton, MO
Property

Office

217,668 SF
Availability

12 Spaces

74,729 SF
Year Built

1964
For Lease

$32.00/SF/YR
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Sevens Building
Regus
7777 Bonhomme Ave Suite 1800, Clayton, MO
Services

Virtual Office

Open Workspace

Private Office

Dedicated Desk
Amenities

24/7 security

Access to global network

Business address

Business lounge

Cleaning services

Ergonomic furniture

Lounge area

Mail services

Money-back guarantee

Office furniture
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230 South Bemiston Avenue

230 South Bemiston Avenue, Clayton, MO
Property

Office

109,130 SF
Availability

2 Spaces

5,084 SF
Year Built

1964
For Lease

$22.50 - $23.50/SF/YR
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Shaw Park Plaza

1 N. Brentwood Blvd., Clayton, MO
Property

Office

281,562 SF
Availability

4 Spaces

18,102 SF
Year Built

2001
For Lease

$40.50/SF/YR
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Clayton Executive Center I

7930 Clayton Rd , Clayton, St Louis, MO
Property

Office

139,308 SF
Availability

2 Spaces

35,305 SF
Year Built

1982
For Lease

$26.00/SF/YR
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The Plaza in Clayton

190 Carondelet Plaza, Clayton, St. Louis, MO
Property

Office

325,172 SF
Availability

2 Spaces

11,330 SF
Year Built

2002
For Lease

$38.75/SF/YR
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The 222 Building

222 South Central Avenue, Clayton, St. Louis, MO
Property

Office

127,000 SF
Availability

8 Spaces

33,902 SF
Year Built

1968
For Lease

$26.50/SF/YR
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Sevens Building

7777 Bonhomme Ave., Clayton, MO
Property

Office

197,311 SF
Availability

21 Spaces

49,848 SF
Year Built

1972
For Lease

$30.00/SF/YR
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200 South Hanley Road

200 South Hanley Road, Clayton, MO
Property

Office

122,850 SF
Availability

1 Space

30,210 SF
Year Built

1967
For Lease

$18.00/SF/YR
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Parkway Tower

225-235 S Meramec Ave, Clayton, MO
Property

Office

102,600 SF
Availability

10 Spaces

12,043 SF
For Lease

$21.50/SF/YR
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Centene Plaza Building C

7676 Forsyth Blvd., Clayton, MO
Property

Office

617,515 SF
Availability

2 Spaces

39,080 SF
Year Built

2019
For Lease

$45.00/SF/YR
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Pierre Laclede II

7733 Forsyth Blvd, Clayton, MO
Property

Office

361,235 SF
Availability

12 Spaces

105,418 SF
Year Built

1970
For Lease

$32.00/SF/YR
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Hoffmann Building

8000 Maryland Avenue, Clayton, St. Louis, MO
Property

Office

194,045 SF
Availability

1 Space

2,178 SF
Year Built

1983
For Lease Contact for pricing
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Clayton - St. Louis
Serendipity Labs
8112 Maryland Avenue, Clayton, MO
Services

Virtual Office

Open Workspace

Meeting Room

Private Office

Dedicated Desk
Amenities

Complimentary coffee & tea

Free water

High-speed wifi

IT support

Parking

Premium coffee

Printer

Privacy booths

Projector

Receptionist/Secretarial services
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7710-7730 Carondelet Avenue

7730 Carondelet Avenue, Clayton, St. Louis, MO
Property

Office

89,470 SF
Availability

4 Spaces

23,484 SF
Year Built

1989
For Lease

$21.00/SF/YR
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Regions Centre

8182 Maryland Avenue, Clayton, St. Louis, MO
Property

Office

278,800 SF
Availability

9 Spaces

100,152 SF
Year Built

1985
For Lease

$31.00/SF/YR
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Pierre Laclede
Regus
7733 Forsyth Boulevard Suite 1100, Clayton, MO
Services

Virtual Office

Open Workspace

Private Office

Dedicated Desk
Amenities

24/7 security

Access to global network

Business address

Business lounge

Cleaning services

Ergonomic furniture

Lounge area

Mail services

Money-back guarantee

Office furniture
View Details (opens in new window)
Clayton Office Evolution
Office Evolution
231 South Bemiston Avenue Suite 800, St. Louis, MO
Services

Virtual Office

Open Workspace

Meeting Room
Amenities

Bike storage

Complimentary coffee & tea

Free water

High-speed wifi

Parking
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8151 Clayton Road

8151 Clayton Road, Clayton, MO
Property

Office

32,000 SF
Availability

1 Space

2,709 SF
Year Built

1989
For Lease

$25.00/SF/YR
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The 130 Building

130 South Bemiston Avenue, Clayton, St. Louis, MO
Property

Office

73,969 SF
Availability

9 Spaces

19,827 SF
Year Built

1964
For Lease Contact for pricing
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Old Town - 168 North Meramec Avenue

168 North Meramec Avenue, Clayton, St. Louis, MO
Property

Office

59,252 SF
Availability

3 Spaces

24,713 SF
Year Built

1982
For Lease

$23.50 - $28.00/SF/YR
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Francis Place

950 Francis Place, Clayton, MO
Property

Office

61,200 SF
Availability

5 Spaces

8,861 SF
For Lease

$12.00 - $22.00/SF/YR
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Hanley Corporate Tower

101 South Hanley Road, Clayton, St. Louis, MO
Property

Office

346,451 SF
Availability

7 Spaces

44,671 SF
Year Built

1985
For Lease

$33.50/SF/YR
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The Hoffmann Building

8000 Maryland Ave., Clayton, MO
Property

Office

194,045 SF
Availability

15 Spaces

59,002 SF
Year Built

1983
For Lease

$30.00/SF/YR
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Forsyth Pointe - West Tower

8049 Forsyth Blvd, Clayton, MO
Property

Office

220,085 SF
Availability

2 Spaces

5,732 SF
Year Built

2023
For Lease Contact for pricing
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Centene Plaza Building B

7700 Forsyth Blvd., Clayton, MO
Property

Office

465,654 SF
Availability

2 Spaces

55,332 SF
Year Built

2010
For Lease

$45.00/SF/YR
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8235 Forsyth Blvd

8235 Forsyth Blvd, Clayton, St. Louis, MO
Property

Office

244,800 SF
Availability

8 Spaces

55,610 SF
Year Built

2000
For Lease

$31.00/SF/YR
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Bemiston Tower

231 South Bemiston Avenue, Clayton, St. Louis, MO
Property

Office

174,241 SF
Availability

2 Spaces

17,516 SF
Year Built

1982
For Lease Contact for pricing
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PNC Center

120 S Central Ave , Clayton, MO
Property

Office

301,613 SF
Availability

10 Spaces

75,360 SF
For Lease

$31.00/SF/YR
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230 South Bemiston Avenue

230 South Bemiston Avenue, Clayton, MO
Property

Office

109,130 SF
Availability

7 Spaces

14,866 SF
Year Built

1963
For Lease

$23.50 - $25.00/SF/YR
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The Hunter Building

121 Hunter Avenue, Clayton, St. Louis, MO
Property

Office

33,318 SF
Availability

1 Space

5,840 SF
Year Built

1987
For Lease

$21.50/SF/YR
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10 North Hanley Road

10 North Hanley Road, Clayton, MO
Property

Office

33,000 SF
Availability

2 Spaces

26,400 SF
Year Built

1963
For Lease

$23.00/SF/YR
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7801 Clayton Rd

7801 Clayton Rd, Clayton, Saint Louis, MO
Property

Office

6,240 SF
Availability

1 Space

1,658 SF
Year Built

1940
For Lease

$1,900.00/MO
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The Bank of America Building

7800 Forsyth Blvd, Clayton, MO
Property

Office

100,487 SF
Availability

1 Space

4,469 SF
Year Built

1985
For Lease

$29.50/SF/YR
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168 North Meramec Avenue
Alchemy
168 North Meramec Avenue #150, Clayton, MO
Services

Open Workspace

Event Space

Meeting Room

Private Office
Amenities

Gym

High-speed internet

Kitchen

Parking

Professional & social events

Shower

TV/Monitor

Women-focused
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Midvale Building

112 S Hanley Rd Clayton Missouri 63105, Clayton, MO
Property

Office

3,100 SF
Availability

1 Space

3,100 SF
For Lease

$29.50/SF/YR
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Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.

The average rent for office space in Clayton is $28.63 per square foot. The minimum rental rate for office space in Clayton is $26 per square foot. Among listings of office space currently available for lease in Clayton, the maximum rental rate is $33.5 per square foot.

For more details on Clayton office space rent and sales prices, as well as overall market quality and new construction data, see Clayton Office Market Trends.

Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in Clayton, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 30,210 square feet in size for an individual listing.
However, there is a variety of differently sized opportunities below that maximum. For your consideration, the median size of an office space for lease in Clayton is 3,662 square feet, and the average office space size here is 5,826 square feet.

You can find 140 office listing(s) for lease in Clayton, which add up to a total of 898,581 square feet. Availability on the market includes a variety of office use types, such as General Office, Office Building, Creative.

The most common office use type currently available for lease in Clayton is General Office, which is offered in 101 or 72.14% of listings. The second-most frequent office use type listed here is Office Building, which account for 8 or 5.71% of office space currently available.

You can search 2 office sublease listing(s) in Clayton, which amount to a total of 12,185 square feet. Sublease opportunities on the market include General Office, Office Building, Creative.

The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.

Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.

The Clayton office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Roughly 52.86% of total office space listings in the city are in properties rated Class A. Class B office space accounts for 37.14% of spaces listed on the leasing market.

Buildings completed in and since the year 2000 account for 17.24% of office properties in the city and incorporate a total of 1,873,226 square feet. About 10.34% of office space in Clayton is in buildings that have been renovated at least once since 2000.

Out of the office space listings currently available in Clayton, you can find 5 LEED-certified or LEED-proposed option(s). A total of 2 building(s) here earned a LEED-certification — certification level Gold (1), Silver (1). The local market includes 1 LEED-proposed office building(s) awaiting certification in Clayton.

There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.

Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of Clayton? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

Clayton, St. Louis County, MO Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in Clayton: 7,767,205 Sq. Ft.

In 2024 the Clayton office market encompassed 7,767,205 square feet of space. Out of that total, 618,331 square feet were in office properties sized between 500,000 and 1,000,000 square feet. Meanwhile, 1,030,927 square feet were in office buildings sized between 50,000 and 100,000 square feet.
Class A office space makes up a 66.24% share of Clayton office inventory, while Class B office assets represent roughly 32.38% of the market total.

Clayton Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	1,030,927 Sq. Ft.	13.27%
100k to 500k Sq. Ft.	5,781,089 Sq. Ft.	74.43%
500k to 1M Sq. Ft.	618,331 Sq. Ft.	7.96%

Clayton Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	5,145,047 Sq. Ft.	66.24%
Class B	2,515,082 Sq. Ft.	32.38%
Class C	107,076 Sq. Ft.	1.38%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

Clayton, St. Louis County, MO Office Spaces for Rent

Frequently Asked Questions

How much does office space cost in Clayton, MO?

How much office space do I need?

What types of office space can I lease in Clayton, MO?

Can I find sublease office space in Clayton, MO?

Where is the best location for office space in Clayton, MO?

How long is the average commute to work in Clayton, MO?

Where can I find the highest quality office space in Clayton, MO?

How do I find the best office space in Clayton, MO?

How can I find office space for rent near me?

Clayton, St. Louis County, MO Office Inventory Breakdown

Total Office Space in Clayton: 7,767,205 Sq. Ft.

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